Having the Daemon's Tail trinket changes the chances to get various rewards from a Red Chest.

Red Chests inside a Devil Room cannot teleport the player to the Devil Room.

If the Devil/Angel Room has not been encountered normally on the floor yet, it will actually change what's in the deal.

Teleport to the Devil Room or Angel Room.

2 Spiders or 2 Striders in Downpour/ Dross.

If Isaac is holding The Left Hand trinket, all chests will turn into Red Chests. Red Chests are most commonly found in Curse Rooms and Devil Rooms, but can also occasionally replace normal chests.

33% chance for one of the following trinkets to add to the random pickups:.

Hearts have a 50% chance to count as 2 batches.

Poker Chip 50% chance to double pickups, 50% for no pickups and an attack fly.

Lucky Toe 33% chance to increase pickups by 1.

If Isaac has Mom's Key, an additional batch of 2-3 pickups spawns, up to a total of 4-6. The same batch can be chosen multiple times.

Pickups: If a chest spawns pickups, 2-3 of the following batches of pickups will spawn.

When opened, they will contain one of the following:

Normal chests have no requirements to open.

Flat file wood